ENDOTHELlUM·DEPENDENT RELAXATION OF BLOOD VESSELS
نویسنده
چکیده
.......................................................................................................... xi 1. ENDOTHELIUM-DEPENDENT VASODILATION: A REViEW ..................................... 1 What is the Nature of the Cholinergic, Endothelium-Dependent Response? 1 Endothelium-Derived Relaxing Factor ................................................. 2 Influence of Contractile Agent and Tone ................................................ 5 Effect of Oxygen Tension and Temperature ........................................... 6 The Role of Cyclic Guanylate Monophosphate (cGMP) ......................... 7 The Role of Calcium Ion ........................................................................ 9 What is the Nature of EDRF? ..................................................................... 12 Half-life ............................................................................................ 12 A Possible Role for Arachidonic Acid Metabolism ............................. 12 Inhibition by Antioxidants and Free Radical Scavengers ........ .......... 16 Other Inhibitors of EDRF................................................................... 17 Summary ........................................................................................... 19 What is the Role of Endothelium with Other Vasodilators? ...•................... 20 Calcium lonophore, A23187 ............................................................. 20 Histamine........................................................................................... 21 Substance P ...•.................................................................................... 23 The Purines (ATP, ADP, Adenosine) ................................................. 24 Bradykinin......................................................... ................................ 26 Arachidonic Acid ................................................................................ 28 Aggregating Platelets, Serotonin, Thrombin and Vasopressin........................................................................................ 29 Flow Rate. .... ...................... .... ........ .............. ...... .......... .......... ............ 31 Catecholamines . ...... ............ ...... .............. ...... .......... .......... ................. 32 Other Agents....................................................................................... 33
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